Which Compound to Select in Lead Optimization? Prospectively Validated Proteochemometric Models Guide Preclinical Development
نویسندگان
چکیده
منابع مشابه
Which Compound to Select in Lead Optimization? Prospectively Validated Proteochemometric Models Guide Preclinical Development
In quite a few diseases, drug resistance due to target variability poses a serious problem in pharmacotherapy. This is certainly true for HIV, and hence, it is often unknown which drug is best to use or to develop against an individual HIV strain. In this work we applied 'proteochemometric' modeling of HIV Non-Nucleoside Reverse Transcriptase (NNRTI) inhibitors to support preclinical developmen...
متن کاملPreclinical Evaluation of a Novel Fiber Compound MR Guide Wire
N. A. Kraemer, S. Krueger, S. Schmitz, M. Linssen, H. Schade, S. Weiss, R. W. Guenther, A. Buecker, and G. A. Krombach Diagnostic Radiology, RWTH Aachen, Aachen, Germany, Imaging Systems and Intervention, Philipps Research Europe, Hamburg, Germany, Fraunhofer Institute for Production Technology, Aachen, Germany, Hemoteq GmbH, Wuerselen, Germany, Andramed GmbH, Reutlingen, Germany, Diagnostic an...
متن کاملWhich factors might lead you to select a surgical or hybrid approach to treat deep venous obstruction?
Which factors might lead you to select a surgical or hybrid approach to treat deep venous obstruction? First, the endovascular technique has clearly surpassed surgical therapy as the primary treatment strategy. Theoretically, one might still consider bypass surgery when all other procedures failed. However, taking into consideration the reason for failure (ie, lack of inflow), bypass surgery wo...
متن کاملImaging to select and guide transcatheter aortic valve implantation.
Transcatheter aortic valve implantation (TAVI) is indicated for patients with severe aortic stenosis and high or prohibitive surgical risk. Patients' selection requires clinical and anatomical selection criteria, being the later determined by multimodality imaging evaluation. Echocardiography, multislice computed tomography (MSCT), angiography, and cardiovascular magnetic resonance (CMR) are th...
متن کاملPractical guide for validated memristance measurements.
Chua [IEEE Trans. Circuit Theory 18, 507-519 (1971)] predicted rather simple charge-flux curves for active and passive memristors (short for memory resistors) and presented active memristor circuit realizations already in the 1970 s. The first passive memristor has been presented in 2008 [D. B. Strukov, G. S. Snider, and D. R. Williams, Nature (London) 453, 80-83 (2008)]. Typically, memristors ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS ONE
سال: 2011
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0027518